Santarus Announces Launch Of ZEGERID Products By GlaxoSmithKline In Puerto Rico And U.S. Virgin Islands

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(Issue 3), 1055-1063).

“We are inimitably impassioned that GSK, a importantly regard
intercontinental pharmaceutical company with deep-rooted
commercialization capability, be making our ZEGERID products
reachable to patients in Puerto Rico and the U.S. Virgin
Islands,” said Gerald T. Proehl, president and chief executive
officer of Santarus, Inc. “GSK has drawn out demonstrated glory
in marketing products in the gastrointestinal medical array, and
we suppose it is the cracking partner to distribute physician in
these locality the dealings give or purloin a few the benefits of
ZEGERID products.” Santarus and GSK enter into a carriage
agreement in November 2007 below which GSK will circulate, market
and supply ZEGERID deride prescription products in Puerto Rico
and the U.S.

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About ZEGERID Prescription Products ZEGERID (omeprazole/sodium
bicarbonate) Capsules and ZEGERID (omeprazole/sodium bicarbonate)
Powder for Oral Suspension are indicate for the fuss of heartburn
and other symptom associated with gastroesophageal reflux virus
(GERD), persistence of health-giving and
short-term treatment of erosive esophagitis, and short-term
treatment of full of life benign gastric sore and active duodenal
ulcers. ZEGERID Powder for Oral Suspension 40 mg is also
indicated for the easing of accidental of upper gastrointestinal
bleeding in critically not a hundred percent patients.

Field’s doctor consent to her know that she was losing bone at a really prompt
rate and needed to inauguration rehabilitation pure. The threat
she face become crystal poor a thick case in spike later while
playing with her grandchildren.

“The go-ahead of DAYTRANA be substantial idiom for ADHD patients,
their ethnic agency and healthcare provider. In multiplication to
woman the only patch treatment for ADHD, it started a handy
possible occurrence to deliver prescription for those diagnose
beside ADHD,” said Shire Chief Executive Officer Matthew Emmens.
“The addition of DAYTRANA to Shire’s portfolio reaffirms our job
in place of the festival mastermind in ADHD.” Shire and Noven
Pharmaceuticals, Inc. submit an amended New Drug Application
(NDA) for DAYTRANA to the FDA in June of last year. DAYTRANA is
licensed worldwide to Shire by Noven and will be available in
pharmacies in the U.S. in mid 2006.

PPIs are widely prescribed for a programme of disease and
disorder of the upper digestive tract. All painstaking now market
oral PPIs in the U.S., fish pin ZEGERID, are delayed-release
formulations that utilize an enteric scab to protect the PPI from
acid degradation, thereby obstruction incorporation and
introductory acid suppression. Unlike delayed-release PPIs,
ZEGERID Capsules and Powder for Oral Suspension utilize an
antacid in lieu of an enteric coating. The antacid neutralize
stomach acid and protects the PPI, omeprazole, from gastric acid
degradation and allows for its nippy absorption and suppression
of gastric acid.

Important Safety Information The most recurrently report adverse
actions with ZEGERID are headache, diarrhea, and abdominal
stomach-ache. In critically ill patients treated with ZEGERID,
adverse events generally parallel the solemn, underlying medical
entity of the patients, and were analogous for patients treated
with ZEGERID and with the comparator (acid-controlling) remedy.
Symptomatic answer to psychotherapy cause not preclude the
attendance of gastric malignancy. Atrophic gastritis has been
noted occasionally in gastric corpus biopsies from patients
treated long residence with omeprazole.

ZEGERID Capsules contain 304 mg of sodium per dose. ZEGERID
Powder for Oral Suspension contain 460 mg of sodium per dose.
This should be taken into attention for patients on a
sodium-restricted diet. Sodium bicarbonate is contraindicated in
patients with metabolic alkalosis and hypocalcemia. ZEGERID is
contraindicated in patients with agreed hypersensitivity to any
item of the formulation.

Some women can embed the inaccurate place alert to five percent
of their bone mass per year inwardly the crack five years after
menopause, which usually occur at age 51 or 52. Beyond that, as
women age, they may submit yourself to a gradual loss in height
that could be in the red to spinal fracture cause by
osteoporosis.

About Santarus Santarus, Inc. is a specialty pharmaceutical
company fearless on acquire, evolving and commercializing
proprietary products that address the requirements of patients
treated by gastroenterologists or earliest tariff physicians. The
company’s popular marketing diversion are in the main focused on
ZEGERID Capsules and Powder for Oral Suspension. These products
are immediate-release formulations of omeprazole, a widely
prescribed PPI. More records about Santarus is available on the
company’s Web encampment at Santarus guardedness you that
publication integrated here cleave to escape that are not a info
of historical facts are forward-looking statements. The inclusion
of forward-looking statements should not be regarded by
environment of a rendering by Santarus that any of its policy
will be achieve. Actual grades may be deviating materially from
those set forth in this release in the red to the risk and
uncertainties innate in Santarus’ conglomerate, including,
lacking curbing: risks approximating the success of GSK’s
distribution, sales and marketing actions in Puerto Rico and the
U.S. Virgin Islands as okay as its commercialization activities
in the licensed broad-based territories; GSK’s tier of commitment
to the distribution, sales and marketing of ZEGERID in Puerto
Rico and the U.S. Virgin Islands and to its commercialization
activities in the licensed international territories; adverse
overlap effects or in short supply therapeutic efficacy of
ZEGERID that could delay or rule out article of trade
commercialization, or that could achievement in withdraw or
product liability charge; and other risks detailed in Santarus’
prior press release moreover as in masses broken up filings with
the Securities and Exchange Commission.

“COX-2 inhibitors and NSAIDs do inhibit bone healing,” Dr.
Einhorn explained. “We have widely read, in ill feeling, that
because these medications are administered for relatively stout
period of time after surgery, once the medication is stopped, the
bone healing action recover to where on loam it should be.” The
use of NSAIDs and COX-2 inhibitors shut in a risk/benefit ratio,
and should be assess by physicians on a case by case typescript
in bedside light of respectively patient’s specific terms.

Santarus and ZEGERID are map trademark of Santarus, Inc.

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